A Dose Response Study Of Oral clonidine as premedication in patients undergoing abdominal gynaecological surgery

Background: The current study was designed to investigate the safe and effective dose of oral clonidine onpost-operative analgesia in patients undergoing gynaecological laparotomy. objective see theeffectiveness Clonidine as a preanesthetic medication determine which givesbetter analgesic effect. Method: In this prospective, randomized, double-blind, controlled sixty adult female ASA physicalstatus I & II aged 18-40 yrs, laparotomy received low 2-2.5mcg/kg (n=30)and high 4-4.5mcg/kg (n=30).These drugs were administered 105 min before estimated time ofinduction anesthesia. Heart rate arterial pressure recorded prior induction, 5 intervally upto 20 minin peroperative 2 hour 6 hours postoperative period. Group-A (clonidine2-2.5mcg/kg) mean heart ranged from73.80 ±8.69 71.45±5.80, Group-B decreased morefrom 70.85±7.64 67.85±6.47. Systolic blood (low clonidine) 113.00±7.32, inGroup-B (high 120.00±10.38 where p=0.024. Diastolic doseclonidine) 76.15±5.29, Group-B(high 80.10±5.3. Postoperative pain assessed by ablinded observer using VAS scale. This done department anesthesiology Apollo HospitalsDhaka over period six months. Results: Patients group A dose) B showed no significant hemodynamic changesbetween groups. Five marked hypotension bradycardia treatedaccordingly.Group more post operative compared A. Conclusion: These data suggest that (100mcg/kg) premedication is facilitatepost-operative with stable haemodynamics without any side effects. On other hand,.high doseclonidine op &.marked bradycardia. JBSA 2022; 35 (2) : 12-16